The Human Genome Program is a coordinated, multi disciplinary, goal oriented research effort aimed at developing technologies that will lead to a detailed understanding of the human genome at the molecular level. The Medical Applications and Biophysical Research Division plans and manages research to develop (1) advanced sequencing technologies that will enable sequencing rates up to one million bases per day and (2) automation of all stages of chromosomes mapping and sequencing for greater efficiency and cost effectiveness. Integrated, collaborative multi disciplinary approaches are encouraged in this program. Research on new sequencing technology includes development of advanced, highly multiplexed capillary gel electrophoresis systems, electrophoresis separations in liquid media without gels, and applications of mass spectrometry and flow cytometry to analysis of sequencing fragments. Robotic systems are being applied in sample preparation procedures, replication of DNA by the polymerase chain reaction, and synthesis of oligonucleotide arrays. This program is being redirected and program notices initiating grant applications may be issued during F.Y. 1998

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